Cat#:PA-3499F;Product Name:Mouse Anti-Human CDKN1A Antibody;Synonym:CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; OTTHUMP00000016297; OTTHUMP00000016298; DNA synthesis inhibitor; CDK-interacting protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6;Background:p21WAF1/Cip1 is a 21 kDa protein belonging to the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors. Cyclin/CDK complexesfacilitate the transition of the cell cycle from G1 to S phase through different steps, while p21WAF1/Cip1 is able to regulate and arrest the cellcycle by interaction with cyclin/CDK complexes. Additionally, p21WAF1/Cip1 can inhibit DNA replication by binding proliferating nuclearantigen (PCNA), and it has been found to participate in a number of other specific protein-protein interactions, some of which areassociated with cell cycle control. Expression of p21WAF1/Cip1 is induced by wild type p53. Induction of p21WAF1/Cip1 expression can, however, also occur in a p53independent manner. Increased expression of p21WAF1/Cip1 is not necessarily linked to growth arrest, and this protein plays a dual functionas both an inhibitor of cyclin/CDK activity, and a positive modulator of cyclin/CDK complex formation and nuclear localization.A dramatical reduction or a total absence of p21WAF1/Cip1 has been shown in tumour cell lines lacking p53 or containing a non-functionalmutant form of p53. Furthermore, numerous studies have revealed that decreased expression of p21WAF1/Cip1 is frequent in humancancers, including gastric, gall bladder, colorectal and endometrial carcinomas.;Description:Mouse Anti-Human CDKN1A Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:SX129;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;