Cat#:PA-3501F;Product Name:Mouse Anti-Human CDKN1A Antibody;Synonym:CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; OTTHUMP00000016297; OTTHUMP00000016298; DNA synthesis inhibitor; CDK-interacting protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6;Background:This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.;Description:Mouse Anti-Human CDKN1A Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:WA-2;Isotype:IgG1;Application:ELISA, IHC, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;