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Protein Crystallization Service

Advanced Biomart has developed a unique and comprehensive protein crystallization platform available to remove the drug target structure determination bottleneck. We offer high resolution structure determination by X-ray crystallography to support both stand-alone and integrated drug discovery projects for the pharmaceutical and biotech industry as well as to academic groups.

One of the most effective techniques for determining protein structures is X-ray crystallography. X-ray crystallography is a scientific method used to determine the arrangement of atoms of a crystalline solid in three dimensional space. Advanced Biomart has several years of experiences in providing gene to crystal structure service, including construction design, protein expression and purification, high-throughput screen of crystallization conditions, compound or fragments soaking and structure determination.
Protein Crystallization Service includes:

►Crystallization condition screen
►X-ray diffraction data collection
►Co-crystallization of Protein-compound; Fragment screen by soaking or co-crystallization
►Determination of structure
Key Features of Protein Crystallization Service:

♦ High Quality
♦ Experienced Scientists
♦ Instruments: TOF LC-MS, Clonpix, Mosquito nano-liter robot, AKTAs, HPLC, Wave bioreactors, Mass spectroscopy, et al.
♦ Cost Effective
♦ Fast & Reliable


Steps Items Timeline Comments
1 Crystallization condition screen by Mosquito 3-9 weeks Commercial screen kits, Sparse matrix screen, 18 ℃ and 4 ℃
2 X-ray diffraction data collection at Synchrone 3-9 weeks Collected at SSRF weekly
3 A. Co-crystallization of Protein-compound
B. Fragment Screen by soaking or co-crystallization
3-9 weeks Binding affinity date of compounds with protein is crucial
4 Determination of structure TBD Phase solved by MR, SeMet or MIR

Contact us now for more information about our protein crystallization services, we will send you a quotation within 24h.

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