- Tel:1-862-686-3631
- Fax: 1-323-978-5598
- Email: [email protected]
One of the most effective techniques for determining protein structures is X-ray crystallography. X-ray crystallography is a scientific method used to determine the arrangement of atoms of a crystalline solid in three dimensional space. Advanced Biomart has several years of experiences in providing gene to crystal structure service, including construction design, protein expression and purification, high-throughput screen of crystallization conditions, compound or fragments soaking and structure determination.
Protein Crystallization Service includes:
►Crystallization condition screen
►X-ray diffraction data collection
►Co-crystallization of Protein-compound; Fragment screen by soaking or co-crystallization
►Determination of structure
Key Features of Protein Crystallization Service:
♦ High Quality
♦ Experienced Scientists
♦ Instruments: TOF LC-MS, Clonpix, Mosquito nano-liter robot, AKTAs, HPLC, Wave bioreactors, Mass spectroscopy, et al.
♦ Cost Effective
♦ Fast & Reliable
| Steps | Items | Timeline | Comments |
| 1 | Crystallization condition screen by Mosquito | 3-9 weeks | Commercial screen kits, Sparse matrix screen, 18 ℃ and 4 ℃ |
| 2 | X-ray diffraction data collection at Synchrone | 3-9 weeks | Collected at SSRF weekly |
| 3 |
A. Co-crystallization of Protein-compound B. Fragment Screen by soaking or co-crystallization |
3-9 weeks | Binding affinity date of compounds with protein is crucial |
| 4 | Determination of structure | TBD | Phase solved by MR, SeMet or MIR |
Contact us now for more information about our protein crystallization services, we will send you a quotation within 24h.
