Advanced Biomart has developed a unique and comprehensive protein crystallization platform that enables high-resolution structure determination through X-ray crystallography, addressing the bottleneck in drug target structure determination. X-ray crystallography is one of the most powerful techniques for determining protein structures and is a commonly used structural biology technique for determining the three-dimensional structures of proteins and other biomolecules.
With years of experience, Advanced Biomart provides a range of services from gene to crystal structure, including structure design, protein expression and purification, high-throughput screening of crystallization conditions, compound or fragment soaking, and structure determination.
Protein Crystallization Service includes:
►Crystallization condition screen
►X-ray diffraction data collection
►Co-crystallization of Protein-compound; Fragment screen by soaking or co-crystallization
►Determination of structure
Key Features of Protein Crystallization Service:
♦ High Quality
♦ Experienced Scientists
♦ Instruments: Refrigerated centrifuge,Crystallization screening instrument,X-ray diffractometer,X-ray generator,Goniometer
♦ Cost Effective
♦ Fast & Reliable
Steps | Items | Timeline | Comments |
1 | Crystallization condition screen by Mosquito | 3-9 weeks | Commercial screen kits, Sparse matrix screen, 18 ℃ and 4 ℃ |
2 | X-ray diffraction data collection at Synchrone | 3-9 weeks | Collected at SSRF weekly |
3 |
A. Co-crystallization of Protein-compound B. Fragment Screen by soaking or co-crystallization |
3-9 weeks | Binding affinity date of compounds with protein is crucial |
4 | Determination of structure | TBD | Phase solved by MR, SeMet or MIR |
Contact us now for more information about our protein crystallization services, we will send you a quotation within 24h.