Cat#:PA-3500F;Product Name:Mouse Anti-p21 Antibody;Synonym:CDKN1A; P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1A (p21, Cip1); CDK-interacting protein 1; OTTHUMP00000016298; WAF1; CDK-interaction protein 1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDKN1; melanoma differentiation associated protein 6; wild-type p53-activated fragment 1; p21CIP1; MDA6; p21Cip1/Waf1; PIC1; Melanoma differentiation-associated protein 6; MDA-6; OTTHUMP00000016297;Background:p21 / WAF1 also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2). p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This was a major discovery in the early 1990s that revealed how cells stop dividing after being exposed to damaging agents such as radiation. In addition to growth arrest, p21 can mediate cellular senescence and one of the ways it was discovered was as a senescent cell-derived inhibitor. The p21(CIP1/WAF1) protein can also interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.;Description:Mouse Anti-p21 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:WA-2;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;