Cat#:PA-778F;Product Name:Mouse Anti-PTEN (Tumor Suppressor) Antibody;Synonym:phosphatase and tensin homolog; BZS; DEC; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MGC11227; EC 3.1.3.67; OTTHUMP00000020032; EC 3.1.3.16; EC 3.1.3.48; phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatase and tensin-like protein; mutated in multiple advanced cancers 1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10;Background:This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.;Description:Mouse Anti-PTEN (Tumor Suppressor) Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:6H2.2;Isotype:IgG;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;