Cat#:PA-777F;Product Name:Mouse Anti-Human PTEN Antibody;Synonym:PTEN; BZS; MGC11227; ADSF; FIZZ3; HXCP1; RSTN; XCP1; resistin; MHAM; MMAC1; PTEN1; TEP1; MGC126603; MGC126609; phosphatase and tensin homolog; Adipose tissue-specific secretory factor; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3; found in inflammatory zone 3; Phosphatase and tensin homolog (mutated in multiple advanced cancers 1);Background:PTEN (phosphatase and tensin homolog deleted on chromosome ten) is a tumor suppressor gene that is mutated in a wide range of cancers.1-4 PTEN is located on chromosome sub-band 10q23.3 and encodes a 403 amino acid protein which acts as a dual-specific protein and phospholipid phosphatase. As a lipid phosphatase, PTEN regulates phosphatidylinositol-3’-kinase by dephosphorylating the D3 position of phosphatidylinositol (3, 4, 5)-triphosphate and phosphatidylinositol (3, 4)-biophosphate substrates, thereby antagonizing signal transduction downstream of phosphatidylinositol-(PI-3) kinase.7 Loss-of-function mutations in the PTEN gene lead to constitutive activation of multiple signaling pathways including the PI3K/Akt pathway which affects cell proliferation, apoptosis and migration.8, 9 PTEN has also been shown to control p53 protein levels and transcriptional activity.;Description:Mouse Anti-Human PTEN Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:6H2.2;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;