Cat#:PA-3053F;Product Name:Monoclonal Mouse Anti-Human Estrogen Receptor α;Synonym:ER; ESR; ERα; ESRA; NR3A1; DKFZp686N23123; estrogen receptor; ER-alpha; OTTHUMP00000017718; OTTHUMP00000017719; estradiol receptor; estrogen receptor αlpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor αlpha 3*, 4, 5, 6, 7*/822 isoform; estrogen receptor αlpha delta 4*, 5, 6, 7*/654 isoform; estrogen receptor αlpha delta 4*, 5, 6, 7, 8*/901 isoform; estrogen receptor αlpha delta 3*, 4, 5, 6, 7*/819-2 isoform; estrogen receptor αlpha delta 3*, 4, 5, 6, 7*, 8*/941 isoform;Background:Steroid hormone receptors exhibit a high affinity and specificity for their ligands. The human estrogen receptor (ER) exists in two forms, ERα and ERβ. The receptors have a high degree of homology in their DNA binding and ligand binding domains and can form heterodimers. However, the two ERs signal in different ways; for example, ERβ does not potentiate the nuclear transcription factor AP-1 when complexed with oestradiol, whereas ERα does. This suggests that ERα and ERβ may have different roles in gene regulation and their relative levels within tissues may influence cellular responses to oestrogens.In breast cancer, the measurement of ERα status is generally recognized as being useful because the presence of ERα is related to an improved overall survival and a favourable response to endocrine therapy.;Description:Monoclonal Mouse Anti-Human Estrogen Receptor α;Host Species:Mouse;Species Reactivity:Human;Clone#:1E6;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;