Cat#:PA-3055F;Product Name:Monoclonal Rabbit Anti-Human Estrogen Receptor α;Synonym:ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123; estrogen receptor; ER-alpha; OTTHUMP00000017718; OTTHUMP00000017719; estradiol receptor; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha 3*, 4, 5, 6, 7*/822 isoform; estrogen receptor alpha delta 4*, 5, 6, 7*/654 isoform; estrogen receptor alpha delta 4*, 5, 6, 7, 8*/901 isoform; estrogen receptor alpha delta 3*, 4, 5, 6, 7*/819-2 isoform; estrogen receptor alpha delta 3*, 4, 5, 6, 7*, 8*/941 isoform;Background:Steroid receptors exhibit a high affinity and specificity for their ligands. The human estrogen receptor (ER) is a dimeric protein of 65 kDa located primarily on the membrane of cell nuclei and belongs to a class of trans-acting proteins which stimulate transcription by binding to specific DNA elements, also known as hormone response elements. Through binding estrogen, the ER is induced to stimulate gene transcription, hence is also known as an inducible enhancer factor.Historical studies have shown that ER status is correlated with untreated outcome (i.e., prognostic for well differentiated invasive breast cancer) and with response to anti-hormonal therapy e.g., tamoxifen. Estrogens have been found to be preferentially concentrated in the estrogen target organs of animals and in human breast cancers and it is well documented that the mitogenic effects of estrogen are mediated by ER. Investigations into the biological mechanisms for breast cancer growth have found that the growth rate is dependent on the presence of estrogen or progesterone or both in most breast cancers. Thus, estrogen receptor status in mammary carcinomas is considered to be a validated prognostic and predictive factor for patient management for anti-hormonal therapy.;Description:Monoclonal Rabbit Anti-Human Estrogen Receptor α;Host Species:Rabbit;Species Reactivity:Human;Clone#:SQ2;Isotype:N/A;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;