Cat#:PA-3052F;Product Name:Monoclonal Mouse Anti-Human Estrogen Receptor β1;Synonym:Erb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA; estrogen receptor beta; OTTHUMP00000180647; estrogen receptor beta 4; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; nuclear receptor subfamily 3 group A member 2;Background:Two human estrogen receptor (ER) subtypes, ERα and ERβ, have been defined. They are encoded by two genes located on different chromosomes. In addition to ERβ1, a number of ERβ isoforms and splicing variants have been identified. Common for the ERs is a high degree of homology in their DNA-binding domains, a conservation of key amino acids within their ligand-binding domains, and their ability to form heterodimers. However, ERα and ERβ have distinct cellular distribution, regulate separate sets of genes, and can oppose each other’s action on some genes.Results from a number of studies suggest a loss of ERβ expression or a decreased expression in many cancers, including breast, ovary and colon, compared with the expression in the corresponding normal tissues, and alteration in the ERα/ERβ ratio is proposed to govern tumour development. In prostatic neoplasia the expression of ERβ appears complex, thus ERβ, as detected with anti-ERβ, clone PPG5/10, has been reported to be partially lost in high grade prostatic intraepithelial neoplasia (HGPIN) and in androgen-insensitive stages of prostatic adenocarcinoma, while it is retained in untreated primary and metastatic prostatic adenocarcinoma. When details of the role of ERβ in cancer biology is better understood, ERβ may become a novel target protein for tumour therapy.;Description:Monoclonal Mouse Anti-Human Estrogen Receptor β1;Host Species:Mouse;Species Reactivity:Human;Clone#:PPG5/21;Isotype:IgG2a;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;