Cat#: | RP-1530H |
Product Name: | Recombinant Human TNFRSF12A / FN14 / TWEAKR Protein (Fc Tag) |
Synonym: | FN14; CD266; TWEAKR; TNF receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14 |
Gene Introduction: | TNFRSF12A, the full name is TNF receptor superfamily member 12A. Gene ID is 51330. Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene. |
Description: | A DNA sequence encoding the human TNFRSF12A isoform 1 (Q9NP84-1) extracellular domain (Glu 28-Trp 79) was fused with the Fc region of human IgG1 at the N-terminus. |
Source: | Human Cells |
Predicted N Terminal: | Glu |
AA Sequence: | Glu 28-Trp 79 |
Molecular Characterization: | The recombinant human TNFRSF12A protien is a disulfide-linked homodimeric protein. The reduced monomer consists of 313aa and has a calculated molecular weight of 34 kDa. The apparent molecular mass of TNFRSF12A/Fc monomer is approximately 37 kDa in SDS-PAGE under reducing conditions. |
Purity: | Greater than 95% as determined by SDS-PAGE |
Endotoxin: | < 1.0 EU per ug of the TNFRSF12A protein as determined by the LAL method |
Bioactivity: | Please contact us for detailed information |
Formulation: | Recombinant human TNFRSF12A was lyophilized from sterile PBS, pH 7.4 |
Stability: | Recombinant TNFRSF12A Proteins are stable for up to 1 year from date of receipt at -70℃ |
Reconstitution: | Please see related COA for specific instructions. |
Host Species: | Human |
Storage: | Avoid repeated freeze-thaw cycles. In lyophilized state for 1 year (4-8℃); Upon reconstitution under sterile conditions for 2 weeks (4-8℃) or 3 months (-20℃ to -70℃). |
References: | Knockdown of the differentially expressed gene TNFRSF12A inhibits hepatocellular carcinoma cell proliferation and migration in vitro. Wang T, et al. Mol Med Rep, 2017 Mar. PMID 28138696 |