Cat#:PA-2926F;Product Name:Sheep Anti-Mouse Factor IX Antibody;Synonym:Factor IX; Christmas factor; Coagulant factor IX; Coagulation factor 9; Coagulation factor IX (plasma thromboplastic component); F9; Factor 9; FactorIX; FIX; GLA domain; HEMB; MGC129641; MGC129642; Plasma thromboplastic component; PTC; Truncated coagulation factor IX;Background:Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia. Factor IX circulates in the blood as an inactive zymogen at the normal concentration of approximately 3 µg/ml. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca2+ ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X linked disorder, also called hemophilia B or Christmas disease. The disease affects approximately 1 in 50,000 of the population (almost exclusively males).;Description:Sheep Anti-Mouse Factor IX Polyclonal Antibody;Host Species:Sheep;Species Reactivity:Mouse;Isotype:N/A;Application:ELISA, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;