Cat#:PA-703F;Product Name:Rabbit Anti-Mouse Rptor (C-terminal) Antibody;Synonym:Rptor; regulatory associated protein of MTOR, complex 1; Rap; Raptor; mKIAA1303; 4932417H02Rik; RP24-225K18.1; regulatory-associated protein of mTOR; OTTMUSP00000004362; p150 target of rapamycin (TOR)-scaffold protein;Background:mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.;Description:Rabbit Anti-Mouse Rptor (C-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Mouse;Isotype:IgG1;Application:WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;
Rptor; regulatory associated protein of MTOR, complex 1; Rap; Raptor; mKIAA1303; 4932417H02Rik; RP24-225K18.1; regulatory-associated protein of mTOR; OTTMUSP00000004362; p150 target of rapamycin (TOR)-scaffold protein
Gene Introduction:
mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.