Cat#:PA-701F;Product Name:Rabbit Anti-Human RPTOR (N-terminal) Antibody;Synonym:RPTOR; regulatory associated protein of MTOR, complex 1; KOG1; Mip1; KIAA1303; raptor; regulatory associated protein of mTOR; Regulatory-associated protein of mTOR; Raptor; p150 target of rapamycin (TOR)-scaffold protein; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats;Background:mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.;Description:Rabbit Anti-Human RPTOR (N-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Isotype:IgG2a;Application:WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;
RPTOR; regulatory associated protein of MTOR, complex 1; KOG1; Mip1; KIAA1303; raptor; regulatory associated protein of mTOR; Regulatory-associated protein of mTOR; Raptor; p150 target of rapamycin (TOR)-scaffold protein; p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
Gene Introduction:
mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.