Cat#:PA-313F;Product Name:Rabbit Anti-Human TLR6 (N-terminal) Antibody;Synonym:TLR6; toll-like receptor 6; CD286; OTTHUMP00000218187; CD286 antigen; TLR 6; Toll like receptor 6 precursor; OTTHUMP00000218188; OTTHUMP00000158730;Background:The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.;Description:Rabbit Anti-Human TLR6 (N-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Application:WB, IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;