Cat#:PA-314F;Product Name:Rabbit Anti-Human TLR5 (C-terminal) Antibody;Synonym:TLR5; toll-like receptor 5; TIL3; SLEB1; FLJ10052; MGC126430; MGC126431; OTTHUMP00000036039; OTTHUMP00000036040; toll/interleukin-1 receptor-like protein 3; Tlr5; TLR 5; TLR5_HUMAN; Toll/interleukin 1 receptor like protein 3; Toll-like receptor 5; TIL 3; Toll like receptor 5 precursor;Background:This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.;Description:Rabbit Anti-Human TLR5 (C-terminal) Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Application:WB, IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;