Cat#:PA-3074F;Product Name:Rabbit Anti-Human ERBB2 Antibody;Synonym:ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NEU; NGL; HER2; TKR1; CD340; HER-2; HER-2/neu; erbB-2; herstatin; c-erb B2/neu protein; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; EC 2.7.10.1; p185erbB2; CD340 antigen ; MLN 19; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2;Background:c-erbB-2 oncoprotein is a 185 kDa transmembrane tyrosine kinase belonging to the epidermal growth factor receptor (EGFR) family. This family comprises four homologous receptors ErbB-1 (EGFR, HER1), ErbB-2 (HER2/neu), ErbB-3 (HER3), and ErbB-4 (HER4). The c-erbB-2 protooncogene is located on chromosome 17 at q21. Activation of c-erbB-2 oncoprotein, either by homo- or heterodimerization, triggers intracellular signalling events, which are crucial for cell growth, differentiation and survival. Mechanisms promoting receptor dimerizations include ligand binding and high receptor density (overexpression). An overexpression of c-erbB-2 oncoprotein is often a result of gene amplification. c-erbB-2 oncoprotein is frequently overexpressed in human carcinomas, thus 25-30% of human breast carcinomas overexpress this receptor, whereas overexpression has not been found in benign breast disease. In the last two decades, monoclonal antibodies which block activation of c-erbB-2 oncoprotein have been developed and clinical activity of a humanized monoclonal antibody, Herceptin, has been documented.;Description:Rabbit Anti-Human ERBB2 Polyclonal Antibody;Host Species:Rabbit;Species Reactivity:Human;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;