Cat#:PA-3070F;Product Name:Mouse Anti-Human ERBB2 Antibody;Synonym:ERBB2; Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; CerbB2; c erb B2/neu protein; CD340; CD340 antigen; Cerb B2/neu protein; ErbB2; EC 2.7.10.1; ERBB2_HUMAN; HER 2; HER 2/NEU; HER2; HER2/NEU; Herstatin; Homolog 2 (neuro/glioblastoma derived oncogene homolog); Metastatic lymph node gene 19 protein; MLN 19; MLN19; NEU; NEU proto oncogene; Neuro/glioblastoma derived oncogene homolog (avian); Neuro/glioblastoma derived oncogene homolog; Neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine protein kinase erbB 2; Receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase type cell surface receptor HER2; Tyrosine kinase-type cell surface receptor HER2; v erb b2 erythroblastic leukemia viral oncogene homolog 2; v erbb2 avian erythroblastic leukemia viral oncogene; Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); EC 2.7.10;Background:HER2 is a 185 kDa transmembrane tyrosine kinase belonging to the epidermal growth factor receptor (EGFR) family. This family comprises four homologous receptors HER1 (EGFR, ErbB-1), HER2 (neu, ErbB-2), HER3 (ErbB-3), and HER4 (ErbB-4). The HER2 gene is located on chromosome 17 at q21. Activation of HER2, through autophosphorylation at tyrosine residues, is initiated by either by homo- or heterodimerization and triggers intracellular signalling events, which are crucial for cell growth, differentiation and survival. Mechanisms promoting receptor dimerizations include ligand binding and high receptor density (overexpression). An overexpression of HER2 is often a result of gene amplification. Of five reported HER2 tyrosine phosphorylation sites, the phosphorylation of Tyr-1248 is known to be significant for transformation and some data suggest that this site is the sole phosphorylation site responsible for oncogenicity as well as for coupling to the ras/MAP kinase signalling pathway. Thus, phosphorylation at Tyr-1248, specifically recognized by Monoclonal Mouse Anti-Human HER2-pY-1248, clone QN3A, seems important for activation of HER2.;Description:Mouse Anti-Human ERBB2 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:PN3B;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;