Cat#:PA-149F;Product Name:Mouse Anti-Thymidylate Synthase 36kDa Antibody;Synonym:d TMP synthase; EC 2.1.1.45; HsT422; MGC88736; OTTHUMP00000162195; Thymidylate synthase; thymidylate synthetase; TMS; TS; TSase; TYMS; TYMS protein; Tyms thymidylate synthetase;Background:Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase;Description:Mouse Anti-Thymidylate Synthase 36kDa Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Bovine;Clone#:2D8.D22;Isotype:IgG1;Application:EIA, IEP, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;