Cat#:PA-150F;Product Name:Mouse Anti-Human Thymidylate Synthase Antibody;Synonym:TYMS; TS; HsT422; MGC88736; TMS; TSase; thymidylate synthetase; HST422; MGC88736; EC 2.1.1.45; Tsase.;Background:Thymidylate synthase (TS) is a key enzyme in the synthesis of DNA. TS, along with methyl donor 5, 10-methylenetetrahydrofolate, catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) to generate the thymine nucleotides necessary for DNA biosynthesis. TS is also a target for fluorinated pyrimidine drugs such as 5-fluorouracil (5-FU). The active metabolite of 5-FU, FdUMP, competes with dUMP for the active binding site on the TS enzyme. FdUMP forms a ternary complex with TS and 5, 10- methylenetetrahydrofolate, thereby inhibiting the enzyme.2 High levels of TS expression has been associated with poor prognosis and response to 5-FU-based chemotherapy in a variety of cancers including rectal, breast, colorectal, gastric, head and neck, esophageal, pancreatic cancer.;Description:Mouse Anti-Human Thymidylate Synthase Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:TS117;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;