Cat#:PA-987F;Product Name:Mouse Anti-Proliferating Cell Nuclear Antigen Antibody;Synonym:PCNA; proliferating cell nuclear antigen; Cyclin; MGC8367; OTTHUMP00000030189; OTTHUMP00000030189; DNA polymerase delta auxiliary protein;Background:Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. It achieves this processivity by encircling the DNA, thus creating a topological link to the genome. It is an example of a DNA clamp.The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.;Description:Mouse Anti-Proliferating Cell Nuclear Antigen Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:PC21;Isotype:IgG2a;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;