Cat#:PA-986F;Product Name:Mouse Anti-Human PCNA Antibody;Synonym:PCNA; proliferating cell nuclear antigen; MGC8367; proliferating cell nuclear antigen; cyclin; OTTHUMP00000030189; OTTHUMP00000030190; A polymerase delta auxiliary protein;Background:PCNA is a 36 kDa multifunctional protein originally defined as a cyclin because it was found expressed at high levels in cycling cells during the last 5% of the G1-phase and the first 35% of the S-phase. It is now clear that PCNA is neither structurally nor evolutionary related to the cyclin proteins. PCNA is essential for progression through the cell cycle, and antisense PCNA oligonucleotides prevent cells from entering the S-phase of the cell cycle. PCNA has a triple function in life and death of the cells. It is an essential component of the DNA replication machinery, functioning as the accessory protein for DNA polymerase δ required for processive chromosomal DNA synthesis, and DNA polymerase ε required for DNA recombination and repair of DNA damage. Absence or low levels of functional PCNA may drive cells into apoptosis. The PCNA gene is one of the few inducible repair genes following radiation exposure, and it executes cellular responses to stress-repair or apoptosis. Over expression of PCNA is used as a monitor of tumour cell cycle time and is the most frequent change found in tumour cells relative to controls, particularly in those tumour cells showing enhanced radioresistance.;Description:Mouse Anti-Human PCNA Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:PC21;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;