Cat#:PA-226F;Product Name:Mouse Anti-Human Tumor Protein p53 Antibody;Synonym:TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53;Background:The p53 tumor suppressor gene is activated by DNA damage, abnormal growth signals, and other intrinsic and extrinsic stresses. Thistranscription factor regulates genes that can lead to growth arrest, DNA repair or apoptosis. The level of p53 protein is autoregulated throughenzymes, such as MDM2 via ubiquination. In normal cells, the concentration of p53 protein is generally below the detection level ofimmunohistochemical methods. Mutations of the p53 gene are among the most common molecular changes identified in human cancers.These mutations can result in accumulation and overexpression of mutant p53 protein. Many of these mutations occur in the DNA bindingdomain of the protein, which prohibits the mutant p53 from properly binding to the DNA target. Mutations of the p53 gene have beenfound in a range of human tumor types from organs such as lung, colorectum, esophagus, ovary, pancreas, skin, stomach, head and neck, bladder, prostate and many others.;Description:Mouse Anti-Human Tumor Protein p53 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:318-6-22;Isotype:N/A;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;