Cat#:PA-225F;Product Name:Mouse Anti-Human Tumor Protein p53 Antibody;Synonym:TP53; tumor protein p53; p53; LFS1; TRP53; FLJ92943; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; p53 transformation suppressor; p53 tumor suppressor; transformation-related protein 53;Background:p53 is a nuclear phosphoprotein with a molecular mass of 53 kDa. Wild-type p53 protein is present in a wide variety of normal cells, but theprotein has a very short half-life and thus is present in only minute amounts, generally below the detection level of immunocytochemicalmethods. Somatic mutation of the p53 gene is a very frequent event in the development of human neoplasia, and because mutant p53proteins often are much more stable than wild-type p53 protein, the mutant p53 protein accumulates to a high level. As examples, p53protein accumulation was observed in 76% of 212 human malignant lesions, including breast, colon and stomach carcinomas, melanoma, embryonal carcinoma of the testis, transitional carcinoma of the urinary bladder, uterine carcinoma and soft tissue sarcomas.Wild-type p53 protein functions as a transcription factor, i.e. as a modulator which can turn crucial genes either on or off. It also inhibitsDNA replication and is a check-point control molecule for progression of the cell cycle. Furthermore, p53 protein is involved in theregulation of apoptosis. In transfection assays, wild-type p53 behaves as a tumour suppressor, while mutant p53 behaves as adominant transforming oncogene.;Description:Mouse Anti-Human Tumor Protein p53 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:DO-8;Isotype:IgG2b, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;