Cat#:PA-319F;Product Name:Mouse Anti-Human TIMP1 Antibody;Synonym:TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; FLJ90373; tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); Tissue inhibitor of metalloproteinases; TIMP-1; Collagenase inhibitor; OTTHUMP00000023214; Erythroid-potentiating activity;Background:Tissue inhibitor of metalloproteinase 1 (TIMP-1) belongs to a protein family in which 3 other members (TIMP-2, TIMP-3 and TIMP-4) are currently known. The TIMP-1 gene is mapped to the X chromosome, and it codes for a 28.5 kDa glycosylated protein. TIMP-1 comprises 184 amino acids, which include 12 cysteine residues involved in formation of six disulfide bonds. TIMP-1 is capable of inhibiting the activities of all known metalloproteinases and plays a pivotal role in extracellular matrix homeostasis and tissue remodeling processes, including cancer invasion, wound healing and inflammation. TIMP-1 may also affect malignant cell transformation, cell proliferation and regulation of apoptosis. TIMP-1 is expressed in myofibroblast-like cells located at the peripheral invasive front of colorectal adenocarcinomas and only sporadically in the normal mucosa, whereas in colorectal adenomas, TIMP-1 is expressed in areas with focal stromal inflammation at the epithelial-stromal interface. In these tissues, no TIMP-1 is observed in epithelial cells, in vascular cells or in smooth muscle cells. Breast carcinomas display high levels of TIMP-1 RNA transcripts located around tumor blood vessels and in the stroma, especially in the tumor-stroma interface. Additionally, both normal and neoplastic neuroendocrine cells display extensive TIMP-1 expression.;Description:Mouse Anti-Human TIMP1 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:VU8;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;