Cat#:PA-219F;Product Name:Mouse Anti-Human Thyroid Peroxidase Antibody;Synonym:TPO; thyroid peroxidase; MSA; TPX; TDH2A; thyroperoxidase; OTTHUMP00000115303; OTTHUMP00000115304; OTTHUMP00000115535; OTTHUMP00000115536; thyroid microsomal antigen; Thyroid Peroxidase; EC 1.11.1; EC 1.11.1.8;Background:Thyroid peroxidase (TPO) is a transmembrane protein of 107 kDa containing a heme prosthetic group and it is present as a dimer on the apical surface of the thyroid follicular cells. TPO is the primary enzyme involved in thyroid hormone synthesis, catalysing iodide oxidation, iodination of tyrosine residues, and coupling of iodotyrosines to generate the iodothyronines T3 and T4. The TPO gene consists of 17 exons, and is located on the short arm of chromosome 2. Malignant thyroid tumours exhibit an anomaly in TPO resulting in a lower affinity for Anti-TPO, MoAb47. Decreased TPO immunoreactivity is an early event in follicular tumourigenesis, taking place before development of invasiveness in parallel with an acceleration of cell growth and appearance of cell atypia.;Description:Mouse Anti-Human Thyroid Peroxidase Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:MoAb58;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;