Cat#:PA-461F;Product Name:Mouse Anti-Human STAT5B (phosphorylated Tyrsine 694 / 699) MAb;Synonym:STAT5B; signal transducer and activator of transcription 5B; STAT5; OTTHUMP00000198374; transcription factor STAT5B;Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).;Description:Mouse Anti-Human STAT5B (phosphorylated Tyrsine 694/699) MAb;Host Species:Mouse;Species Reactivity:Human;Clone#:5H5;Isotype:IgG1;Application:ELISA, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;