Cat#:PA-881F;Product Name:Mouse Anti-Human PLAUR Antibody;Synonym:PLAUR; plasminogen activator, urokinase receptor; CD87; UPAR; URKR; Urokinase plasminogen activator surface receptor; uPAR; U-PAR; Monocyte activation antigen Mo3; MO3;Background:uPAR, also designated CD87, is the cell surface receptor for the urokinase-type plasminogen activator (uPA). uPAR is a highly glycosylated protein consisting of 283 amino acid residues which is C-terminally linked to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor. uPAR and uPA are both members of the uPA system, which additionally includes 2 endogenous inhibitors; plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2). uPA activates plasminogen to plasmin, which in turn catalyses degradation of components in basement membranes and extra cellular matrix (ECM). Binding of uPA to uPAR increases uPA activity and generates a highly efficient and focused proteolytic system at the cell membrane. uPAR is normally expressed by a subpopulation of macrophages and intravascular neutrophils and expression is increased upon leucocyte activation. In colon adenocarcinomas, uPAR is primarily expressed by macrophages at the tumor-stroma interface and by some budding cancer cells in neoplastic glands located near the invasive leading edge. In breast carcinomas, uPAR is predominantly expressed in tumor infiltrating macrophages at the immediate vicinity of the cancer cells in invasive foci. The uPA system has been implicated in cancer invasion and metastasis. Levels of uPA and uPAR are elevated in many human malignant tumors and high levels are related to tumor invasiveness. However, uPA and uPAR levels in a given tumor type vary considerably between individual patients.;Description:Mouse Anti-Human PLAUR Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:S5;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;