Cat#:PA-1318F;Product Name:Mouse Anti-Human MITF Antibody;Synonym:MITF; microphthalmia-associated transcription factor; MI; WS2; WS2A; bHLHe32; homolog of mouse microphthalmia; OTTHUMP00000195123; OTTHUMP00000195138; OTTHUMP00000195139; OTTHUMP00000195140; OTTHUMP00000195142; OTTHUMP00000213867; OTTHUMP00000213868; OTTHUMP00000230787; class E basic helix-loop-helix protein 32; Waardenburg syndrome, type 2A;Background:MITF (microphthalmia transcription factor) is a basic-helix-loop-helix-leucine-zipper (bHLHzip) transcription factor which regulates the development and survival of melanocytes and retinal pigment epithelium, and is also involved in transcription of pigmentation enzyme genes such as tyrosinase, TRP1 and TRP2.2, 4 MITF has been shown to be phosphorylated by MAP kinase in response to c-Kit activation, resulting in upregulation of MITF transcriptional activity.1 Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A.5 Multiple isoforms of MITF exist including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage;Description:Mouse Anti-Human MITF Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:E6;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;