Cat#:PA-1301F;Product Name:Mouse Anti-Human Membrane Metallo-endopeptidase Antibody;Synonym:NEP; SFE; CD10; CALLA; MGC126681; MGC126707; DKFZp686O16152; neprilysin; Enkephalinase; atriopeptidase ;OTTHUMP00000212961; OTTHUMP00000212963; OTTHUMP00000212964; OTTHUMP00000212965; OTTHUMP00000212966; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); EC 3.4.24.11; MME;Background:Neprilysin, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), CD10, and common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.;Description:Mouse Anti-Human Membrane Metallo-endopeptidase Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:56D7;Isotype:IgG1;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;