Cat#:PA-1302F;Product Name:Mouse Anti-Human CD10 Antibody;Synonym:Neprilysin; enkephalinase; atriopeptidase; CD10 antigen; OTTHUMP00000212961; OTTHUMP00000212963; OTTHUMP00000212964; OTTHUMP00000212965; OTTHUMP00000212966; skin fibroblast elastase; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase; NEP; SFE; CD10; CALLA; MGC126681; MGC126707; DKFZp686O16152; MME; EPN; Enkephalinase; Neutral endopeptidase; Atriopeptidase; Neutral endopeptidase 24.11; Common acute lymphocytic leukemia antigen; EC 3.4.24.11;Background:This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosisof human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, whichrepresent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety ofnormal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush borderof proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at theamino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substanceP, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, existsin a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting infour separate mRNA transcripts. The coding region is not affected by alternative splicing.;Description:Mouse Anti-Human CD10 Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:MEM-89;Isotype:IgG1;Application:FCM, IP;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosisof human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, whichrepresent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety ofnormal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush borderof proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at theamino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substanceP, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, existsin a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting infour separate mRNA transcripts. The coding region is not affected by alternative splicing.
Description:
Mouse Anti-Human CD10 Monoclonal Antibody
Host Species:
Mouse
Species Reactivity:
Human
Clone#:
MEM-89
Isotype:
IgG1
Application:
FCM, IP
Usage:
For Lab Research Use Only
Storage:
Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles
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