Cat#:PA-1504F;Product Name:Mouse Anti-Human LDLR Antibody;Synonym:LDLR; FH; FHC; LDLCQ2; LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; sLOX-1;Background:The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediatedendocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken intothe cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression ofmicrosomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterolsynthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in thisgene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multipletranscript variants.;Description:Mouse Anti-Human LDLR Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:IgG-D8;Isotype:IgG2b;Application:FCM, IFA, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;