Cat#:PA-1535F;Product Name:Mouse Anti-Human Lamin Antibody;Synonym:Lamin (Mixed);Background:Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.;Description:Mouse Anti-Human Lamin Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:X67, X167, X244;Isotype:IgG1;Application:IFA, IHC, WB;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Description:
Mouse Anti-Human Lamin Monoclonal Antibody
Host Species:
Mouse
Species Reactivity:
Human
Clone#:
X67, X167, X244
Isotype:
IgG1
Application:
IFA, IHC, WB
Usage:
For Lab Research Use Only
Storage:
Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles