Cat#:PA-3497F;Product Name:Mouse Anti-Human CDKN1B Antibody;Synonym:KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin-dependent kinase inhibitor 1B; OTTHUMP00000195098; OTTHUMP00000195099; Cyclin-dependent kinase inhibitor p27; p27Kip13; CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1);Background:p27Kip1 is an inhibitor of cyclin dependent kinases. Cyclin-dependent kinases (CDKs), together with their regulatorysubunits, cyclins, are positive regulators of cell-cycle progression in eukaryotic cells. Cyclin-CDK complexes areregulated by the cyclin-dependent kinase inhibitors (CDKIs), which generally inhibit cell cycle progression. Two familiesof CDKIs exist, the Cip/Kip family and the INK4 family. The Cip/Kip family includes p27Kip1, p21WafI/CipI and p57Kip2. TheCip/Kip family members interact with the cyclin-CDK complexes and inhibit kinase activity of cyclin A/CDK2 and cyclinE/CDK2, through binding of a conserved N-terminal domain to the cyclin/CDK complexes. However, the Cip/Kip proteinscan also act as positive regulators of cyclin D/CDK4. In normal cells, increased expression of p27Kip1 mediates G1 arrestinduced by transforming growth factor-β, contact inhibition, rapamycin and other stimuli. Mutation of the p27Kip1 gene hasbeen investigated in a large variety of tumours, however, substitions, deletions or rearrangements of the p27Kip1 geneare rare events.;Description:Mouse Anti-Human CDKN1B Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:SX53H9;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;