Cat#:PA-3628F;Product Name:Mouse Anti-Human CD19 Molecule Antibody;Synonym:CD19; B4; CVID3; MGC12802; B-lymphocyte antigen CD19; OTTHUMP00000122551; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;Background:B-lymphocyte antigen CD19 also known as CD19 (Cluster of Differentiation 19), is a protein that in humans is encoded by the CD19 gene. CD19 is a 120 kDa transmembrane glycoprotein with a reduced Mr of 95 000 (1). CD19 is a member of the immunoglobulin superfamily with two extracellular C2 type domains (2), and it is a critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation (1). CD19 expression is, besides its presence on follicular dendritic cells, restricted to normal and neoplastic B cells, being absent from T cells, monocytes, and granulocytes (2). The CD19 protein appears early during B cell maturation, probably at late pro-B-cell stage around the time of Ig heavy chain rearrangement. It then persists during all stages of B cell maturation and is lost upon terminal differentiation to plasma cells (2). The advantage of immunodetection of CD19 expression is that B linage leukaemias and lymphomas rarely lose the epitope (3). Expression of CD19 in some acute myelocytic leukaemia cells has been described (2). Refer to General Instructions for Immunohistochemical Staining or the detection system instructions of IHC procedures for: 1) Principle of Procedure, 2) Materials Required, Not Supplied, 3) Storage, 4) Specimen Preparation, 5) Staining Procedure, 6) Quality Control, 7) Troubleshooting, 8) Interpretation of Staining, 9) General Limitations.;Description:Mouse Anti-Human CD19 Molecule Monoclonal Antibody;Host Species:Mouse;Species Reactivity:Human;Clone#:LE-CD20;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;