Cat#:PA-2673F;Product Name:Monoclonal Mouse Anti-Human Granzyme B;Synonym:HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; C11; CTLA-1; fragmentin 2; fragmentin-2; OTTHUMP00000178755; OTTHUMP00000228682; cathepsin G-like 1; human lymphocyte protein; T-cell serine protease 1-3E; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2;Background:Granzyme B, a 29 kDa monomer protein, is a member of a subfamily of serine proteases with chymotrypsin-like specificity. For CTL and NK cells to excert their cytolytic activity, the presence of cytoplasmic secretory granules containing granzymes and perforin are pivotal. After granule exocytosis, granzyme B is believed to enter the target cell through a perforin-derived transmembrane channel to induce DNA fragmentation and apoptosis. A high percentage of activated CTL’s, identified by anti-granzyme B, clone GrB-7, and present in tumour biopsies of patients with nodular sclerosis or mixed cellularity Hodgkin’s disease, has been reported to be a strong indicator for an unfavorable outcome.;Description:Monoclonal Mouse Anti-Human Granzyme B;Host Species:Mouse;Species Reactivity:Human;Clone#:GrB-8;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;