Cat#:PA-2674F;Product Name:Monoclonal Mouse Anti-Human Glycophorin C;Synonym:GE; GPC; GPD; GYPD; CD236; PAS-2; CD236R; PAS-2'; MGC117309; MGC126191; MGC126192; glycophorin-C; glycophorin-D; glycoconnectin; glycoprotein beta; OTTHUMP00000162176; OTTHUMP00000203779; sialoglycoprotein D;Background:Glycophorins is a group of membrane sialoglycoproteins with high carbohydrate content. Five different glycophorins exist and they can be subdivided in two groups, each with distinct properties. The first group includes the major proteins glycophorin A and B, carriers of the MN and Ss blood group antigens, and the low level expressed glycophorin E protein. The second group consists of the minor proteins glycophorin C (GPC) and D (GPD) that both carry the Gerbich antigens. GPC contains 128 amino acids and may be involved in the regulation of the mechanical properties of the erythrocyte membrane. GPC is found on all erythrocytes except those from three Gerbichnegative subtypes within the Melanesian population and a fourth category, the Leach phenotype. In contrast to the other glycophorins, GPC is already expressed on erythroid progenitors (burst-forming unit-erythroid and colony-forming unit-erythroid) during normal and leukaemic erythroid differentiation. It is found at the surface of the majority of peripheral blood cells and cell lines with the exception of granulocytes, platelets and some B-lymphoid cell lines. Cells of erythroid origin express higher levels of GPC compared with non-erythroid cell lines of T lymphoid, promonocytic and megakaryocytic origin.;Description:Monoclonal Mouse Anti-Human Glycophorin C;Host Species:Mouse;Species Reactivity:Human;Clone#:Ret41g;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;