Cat#:PA-3112F;Product Name:Monoclonal Mouse Anti-Human EGFR;Synonym:ERBB; HER1; mENA; ERBB1; PIG61; epidermal growth factor receptor; OTTHUMP00000159661; OTTHUMP00000159662; OTTHUMP00000159663; OTTHUMP00000209210; OTTHUMP00000209211; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;Background:Epidermal growth factor receptor (EGFR) is a 170 kD transmembrane glycoprotein which can bind and become activated by various ligands including epidermal growth factor (EGF), transforming growth factor alpha (TGFα) and certain virally encoded growth factors. Ligand binding activates the intrinsic tyrosine kinase activity of the receptor, which is associated with the intracellular domain of the molecule. Activation of the kinase results in the rapid autophosphorylation of the EGFR, and subsequent phosphorylation of other cellular substrates such as phospholipase C-II. A number of signaling events follow, such as the elevation of intracellular calcium, which results in various cellular responses including increased DNA synthesis, cell proliferation and cell differentiation.;Description:Monoclonal Mouse Anti-Human EGFR;Host Species:Mouse;Species Reactivity:Human;Clone#:H22;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;