Cat#:PA-3508F;Product Name:Monoclonal Mouse Anti-Human E-Cadherin;Synonym:UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; OTTHUMP00000174868; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial;Background:E-cadherin is a 120 kD transmembrane cell adhesion molecule. The gene has been localized on chromosome 16q22.1. In its extracellular domain, E-cadherin is involved in cell-cell adhesion through calcium-regulated homophilic interactions, whereas in its intracellular domain, Ecadherin connects to the actin cytoskeleton via catenins. E-cadherin has a significant function in intercellular adhesion of epithelial cells, the establishment of epithelial polarization, glandular differentiation, and stratification. It is localized mainly in the adherens junctions and concentrates the urokinase plasminogen and the epidermal growth factor receptor to cell contact sites. Down-regulation of E-cadherin expression has been observed in a number of carcinomas and is usually associated with advanced stage and progression.;Description:Monoclonal Mouse Anti-Human E-Cadherin;Host Species:Mouse;Species Reactivity:Human;Clone#:NCH-49;Isotype:IgG1, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;