Cat#:PA-3221F;Product Name:Monoclonal Mouse Anti-Human Cytokeratin 10 / 13;Synonym:CK10; CK13; K10; K13; Keratin 10; Keratin 13; KPP; KRT10; KRT13;Background:Cytokeratins are alpha-type fibrous polypeptides with a diameter of 7-11 nm. They are important components of the cytoskeleton in almost all epithelial cells as well as in some non-epithelial cell types. Cytokeratins are, generally, held to be the most ubiquitous markers of epithelial differentiation, and, so far, 20 distinct types numbered by Moll have been revealed. In contrast to other intermediate filaments, cytokeratins are made up of a highly complex multigene family of 40 to 68 kDa polypeptides. They can be divided into an acidic (type I) and a neutral-basic (type II) subfamily. Cytokeratin 10 is an intermediated sized, acidic type I cytokeratin, with a molecular mass of 56.5 kDa, expressed only in epidermis of most body locations. Cytokeratin 10 expression is absent in basal cells but abundently expressed in all suprabasal cells simultaneously with cytokeratin 1. Together they represent one of the first markers of epidermal differentiation. Cytokeratin 13 is also an intermediate sized, acidic type I cytokeratin, although with a molecular mass of 54 kDa. It is a major componentof several non-cornified stratified epithelia, including tongue mucosa, oesophagus, anal canal epithelium, tracheal epithelium, uterine cervix and urothelium.;Description:Monoclonal Mouse Anti-Human Cytokeratin 10/13;Host Species:Mouse;Species Reactivity:Human;Clone#:DE-K24;Isotype:IgG2a, kappa;Application:IHC;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;