Cat#:RP-215AC;Product Name:Recombinant Human EGFR Protein(Strep Tag);Synonym:EGFR,ERBB,ERBB1,HER1,PIG61,mENA;Background:Gene ID: 1956. EGFR, the full name is epidermal growth factor receptor. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016];Description:Human EGF R with Strep Tag is produced in HEK293 cells. It contains AA Leu 25 - Ser 645.;Source:HEK293;Predicted N Terminal:Leu 25;AA Sequence:Leu 25 - Ser 645.;Molecular Characterization:Recombinant Human EGFR Protein has a calculated MW of 76.1 kDa. The recombinant protein migrates as 110-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.;Purity:Greater than 95% as determined by SDS-PAGE.;Endotoxin:< 1.0 EU per μg of recombinant human EGFR protein by the LAL method.;Formulation:Recombinant human EGFR protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4.;Stability:Recombinant human EGFR protein was stable up to 1 year from date of receipt at -70℃;Host Species:Human;Storage:Store recombinant human EGFR protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.;Usage:For Lab Research Use Only;References:Prognostic implication of EGFR gene mutations and histological classification in patients with resected stage I lung adenocarcinoma. Lin CY, et al. PLoS One, 2017. PMID 29065153;