Cat#: | RP-215AC |
Product Name: | Recombinant Human EGFR Protein(Strep Tag) |
Synonym: | EGFR,ERBB,ERBB1,HER1,PIG61,mENA |
Gene Introduction: | Gene ID: 1956. EGFR, the full name is epidermal growth factor receptor. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016] |
Description: | Human EGF R with Strep Tag is produced in HEK293 cells. It contains AA Leu 25 - Ser 645. |
Source: | HEK293 |
Predicted N Terminal: | Leu 25 |
AA Sequence: | Leu 25 - Ser 645. |
Molecular Characterization: | Recombinant Human EGFR Protein has a calculated MW of 76.1 kDa. The recombinant protein migrates as 110-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Purity: | Greater than 95% as determined by SDS-PAGE. |
Endotoxin: | < 1.0 EU per μg of recombinant human EGFR protein by the LAL method. |
Formulation: | Recombinant human EGFR protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4. |
Stability: | Recombinant human EGFR protein was stable up to 1 year from date of receipt at -70℃ |
Host Species: | Human |
Usage: | For Lab Research Use Only |
Storage: | Store recombinant human EGFR protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
References: | Prognostic implication of EGFR gene mutations and histological classification in patients with resected stage I lung adenocarcinoma. Lin CY, et al. PLoS One, 2017. PMID 29065153 |