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Recombinant Human IGF1R / CD221 Protein (His Tag) Online Inquiry

Product Name:Recombinant Human IGF1R / CD221 Protein (His Tag)
Synonym: IGF1R; IGFR; CD221; IGFIR; JTK13; insulin like growth factor 1 receptor
Gene Introduction: Gene ID: 3480. IGF1R, the full name is insulin like growth factor 1 receptor. This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Description: A DNA sequence encoding the extracellular domain (Met 1-Asn 932) of human IGF1 Receptor (NP_000866.1) precursor was expressed with a C-terminal polyhistidine tag.
Source: Human Cells
Predicted N Terminal: Glu 31
Molecular Characterization: The calculated molecular masses for α subunit, β subunit and the single chain of the receptor are approximately 81 kDa, 23 kDa and 104 kDa, respectively. As a result of glycosylation, the recombinant single chain, α subunit and β subunit have apparent molecular masses of approximately 150 kDa, 120 kDa and 48 kDa, respectively in SDS-PAGE under reducing conditions.
Purity: Greater than 90% as determined by SDS-PAGE
Endotoxin: < 1.0 EU per ug of the human IGF1R protein as determined by the LAL method
Bioactivity: Please contact us for detailed information
Formulation: Recombinant Human CD221 Protein was lyophilized from sterile PBS Buffer, pH 7.4
Stability: Recombinant human IGF1R Proteins are stable for up to 1 year from date of receipt at -70℃
Reconstitution: Please see related COA for specific instructions.
Host Species: Human
Usage: For Research Use Only!
Storage: Avoid repeated freeze-thaw cycles. In lyophilized state for 1 year (4-8℃); Upon reconstitution under sterile conditions for 2 weeks (4-8℃) or 3 months (-20℃ to -70℃).
References: Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone. Nordstrand A, et al. Clin Exp Metastasis, 2017 Apr. PMID 28447314

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