Cat#:IGF1R-007RPH;Product Name:Recombinant Human IGF1R Protein(His & GST Tag);Synonym:IGF1R; insulin like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13;Background:Gene ID: 3480. IGF1R, the full name is insulin like growth factor 1 receptor. This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014];Description:A DNA sequence encoding the human IGF1R (NP_000866.1) cytoplasmic domain (Met 954-Cys 1367) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.;Source:Baculovirus-Insect Cells;Predicted N Terminal:Met;AA Sequence:Met 954-Cys 1367;Molecular Characterization:The recombinant human IGF1R (aa 954-1367) /GST chimera consists of 651 amino acids and has a calculated molecular mass of 74.6 KDa.;Purity:Greater than 85% by SDS-PAGE;Endotoxin:< 1.0 EU per μg of the human IGF1R protein as determined by the LAL method;Bioactivity:The specific activity of the human igf1r protein was determined to be 554 nmol/min/mg using Poly(Glu,Tyr) 4:1 as substrate ;Formulation:The IFG1R human was supplied in sterile 20 mM Tris, 500 mM NaCl, 20 % glycerol, pH 7.4.;Stability:Recombinant Human IGF1R Proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Storage:Store the human IGF1R protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.;References:The Prognostic and Clinicopathological Significance of IGF-1R in NSCLC: a Meta-Analysis. Zhao J, et al. Cell Physiol Biochem, 2017. PMID 28946136;