Cat#:RP-1227H;Product Name:Recombinant Human Phospholipase A2 IID / PLA2G2D Protein (Fc Tag);Synonym:phospholipase A2 group IID; SPLASH; sPLA2S; PLA2IID; sPLA2-IID; group IID secretory phospholipase A2; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholipase A2s; secretory-type PLA, stroma-associated homolog;Background:This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012];Description:Recombinant human PLA2G2D (Q9UNK4) (Met1-Cys145), produced in human cells, was expressed with the Fc region of human IgG1 at the C-terminus.;Source:Human Cells;Predicted N Terminal:Gly 21;AA Sequence:Met1-Cys145;Molecular Characterization:The recombinant human PLA2G2D is a disulfide-linked homodimer. The reduced monomer comprises 366 aa and has a predicted molecular weight of 41.5 kDa. The apparent MW of the protein is approximately 44 kDa in SDS-PAGE under reducing conditions;Purity:Greater than 85% as determined by SDS-PAGE;Endotoxin:< 1.0 EU per ug of the human PLA2G2D protein as determined by the LAL method;Bioactivity:Please contact us for detailed information;Formulation:Recombinant human PLA2G2D protein was lyophilized from sterile PBS, pH 7.4.;Stability:Recombinant human PLA2G2D proteins are stable for up to 1 year from date of receipt at -70℃;Reconstitution:Please see related COA for specific instructions.;Host Species:Human;Storage:Avoid repeated freeze-thaw cycles. In lyophilized state for 1 year (4-8℃); Upon reconstitution under sterile conditions for 2 weeks (4-8℃) or 3 months (-20℃ to -70℃).;References:Secretory phospholipase A2 group IID Is involved in progesterone-induced acrosomal exocytosis of human spermatozoa. Li K, et al. J Androl, 2012 Sep-Oct. PMID 22240557;