Cat#:EIA-538C;Product Name:Human Ferritin ELISA Kit;Size:96T;Sample:human serum;Intended use:in vitro diagnosis;Synonym:Cell proliferation-inducing gene 15 protein; Ferritin; Ferritin H subunit; Ferritin heavy chain; Ferritin heavy chain like; Ferritin heavy polypeptide 1; Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; Ferritin light polypeptide like 3; Ferritin mitochondrial; FHC; FRIH; FTH; FTH1; FTHL6; FTL; FTMT; L apoferritin; MGC71996; Mitochondrial ferritin; MTF; PIG15; PLIF;Background:One of the most prevalent disorders of man is the dietary deficiency of iron resulting in anaemia. Therefore, the assays of iron total binding capacity and other assessments of iron compounds in the body are clinically significant. Iron storage compounds in the body include haemoglobin, haemosiderin, myoglobulin and the cytochromes. In most tissues, Ferritin is a major iron storage protein. Human Ferritin has a molecular weight of approximately 45,000 daltons and consists of a protein shell around an iron core; each molecule of Ferritin may contain as many as 4,000 iron atoms. Under normal conditions, this may represent 25% of the total iron found in the body. In addition, Ferritin can be found in several isomers. High concentrations of Ferritin are found in the cytoplasm of the reticuloendothelial system, the liver, spleen and bone marrow. Methods previously used to measure iron in such tissues were invasive, caused patient trauma and lacked adequate sensitivity. The measurement of Ferritin in serum is useful in determining changes in body iron storage and is non-invasive with relatively little patient discomfort. Serum Ferritin levels can be measured routinely and are particularly useful in the early detection of iron-deficiency anaemia in apparently healthy people. Serum Ferritin measurements are also clinically significant in the monitoring of the iron status of pregnant women, blood donors, and renal dialysis patients. High Ferritin levels may indicate iron overload without apparent liver damage, as may be noted in the early stages of idiopathic haemochromatosis. Ferritin levels in serum have also been used to evaluate clinical conditions not related to iron storage, including inflammation, chronic liver disease and malignancy.;Species Reactivity:Human;Application:quantitative;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Sandwich-ELISA;