Cat#:EIA-622C;Product Name:HTLV 1+2 ELISA Kit;Size:192 T;Sample:human serum or plasma;Intended use:IVD;Synonym:HTLV-I; HTLV-II; HTLV-III; HTLV-IV; Human T-lymphotropic virus Type I; Human T-lymphotropic virus Type II; Human T-lymphotropic virus Type III; Human T-lymphotropic virus Type IV; Human T-lymphotropic virus 1; Human T-lymphotropic virus 2; Human T-lymphotropic virus 3; Human T-lymphotropic virus 4; Group VI (ssRNA-RT); Retroviridae'; Orthoretrovirinae; Deltaretrovirus; Simian T-lymphotropic virus; Human T-lymphotropic virus;Background:Human T-cell Lymphotropic Viruses (HTLVs) are pathogenic retroviruses that may cause severe haematological and neurological diseases in infected individuals. The HTLV family comprises of two well-studied members: HTLV-I and HTLV-II, as well as two newly discovered members: HTLV-3 and HTLV-4. HTLV-I is known as the etiological agent of adult T-cell leukemia / lymphoma (ATL), HTLV-associated myelopathy / tropical spastic paraparesis (HAM/TSP), and HTLV-associated uveitis. HTLV-II infection has also been associated with leukemia and neurological disease although it is less pathogenic than HTLV-I. Several lines of molecular evidences suggest that HTLV-3 possesses some of the HTLV-I properties although little is known about the pathogenicity of HTLV-3. Studies of the geographic distribution of HTLV-I infection reveal that the virus is highly prevalent in Japan, Africa, Caribbean islands and South America. Recent epidemiological studies in the United States and Europe confirm the presence of a mixed prevalence of both HTLV-I and HTLV-II among different high-risk populations, such as intravenous drug users and transfusion recipients. The viruses can be transmitted through sexual contact, and through contaminated blood products, and mother to child via breast-feeding. The CD HTLV-I+II is a direct sandwich immunoassay that utilises a combination of recombinant proteins and a tri-fusion recombinant protein labeled with horseradish peroxidase. This test format assures simultaneous detection of various specific IgA, IgG and IgM antibodies against HTLV-I and HTLV-II. In addition, external tests had shown CD HTLV-I+II is capable of detecting antibodies to HTLV-3/STLV-3. The CD HTLV-I+II is intended as a semi-quantitative enzyme-linked immunosorbent assay for the detection of antibodies to both HTLV-I and HTLV-II found in human serum or plasma. It is intended as a first line screen, requiring repeat testing of initially reactive specimens and confirmation of repeat reactive specimens by supplemental assays.;Species Reactivity:Virus;Application:qualitative;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Sandwish ELISA;