Cat#:EIA-626C;Product Name:HSV IgM ELISA Kit;Size:96;Sample:serum or plasma;Intended use:IVD;Synonym:HSV; Herpes simplex virus; HSV epitope; QPELAPEDPED; HSV epitope tag; Group I (dsDNA); Herpesviridae; Alphaherpesvirinae; Simplexvirus;Background:Herpes Simplex virus (HSV) belongs to the Herpes virus group which also includes Cytomegalovirus (CMV), Varicella Zoster Virus (VZV) and Epstein-Barr Virus (EBV). A common characteristic of these viruses is that they can cause latent infections. HSV is among the most common infectious agents of man. The clinical manifestations vary, but may be more severe in certain types of hosts, for instance the newborn or immunocompromised patient and with involvement of certain sites such as the central nervous system. HSV can cause genital, neurological, oral and respiratory infections and is the causative agent of labial herpes, herpetic keratitis and herpes of the skin. Serological diagnosis of HSV infections can be performed by testing for a significant rise in HSV-specific IgG antibodies in paired sera and for HSV-specific IgM antibodies. In general, it is advised to test a combination of IgG and IgM. Specific IgM antibodies are indicative of primary HSV infection and appear usually within the first week after onset of illness. An IgM antibody response also often follows severe secondary herpetic infections, such as meningoencephalitis or eczema herpeticus, but in connection with the appearance of ordinary recurrent orofacial or genital lesions specific IgM antibodies are usually not detectable. Crossreactivity between HSV and VZV may exist and an interpretation of HSV serological results should be related with clinical data. Specific IgG antibody response can be detected by the use of serum pairs in primary or recurrent HSV infections. This assay makes use of whole virus based HSV type 1 antigen. Crossreactivity with HSV-2 antigen may occur. Serological response to HSV may consist of reactivity to HSV common antigens and to type specific antigens. Whole virus based assays can not give reliable data for identifying a type 1 or type 2 infection. Therefore type specific interpretation of results must be done with great care.;Species Reactivity:Virus;Application:qualitative;Storage:Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.;Usage:For Lab Research Use Only;Detection Principle:Capture ELISA;