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TBE IgM ELISA Kit Online Inquiry

Cat#:EIA-142C
Product Name:TBE IgM ELISA Kit
Synonym: Group IV ((+)ssRNA); Flaviviridae; Flavivirus; Tick-borne meningoencephalitis virus; TBEV
Size: 96 T
Sample: Human Serum, Plasma and Cerebrospinal Fluid (CSF)
Intended use: IVD
Gene Introduction: In Europe, FSME (Tick-borne Encephalitis referred to as TBE) and Lyme Disease (Borreliosis) are the most frequent tick-borne infections. Borreliosis is very widespread but TBE is confined to special endemic regions. Both infections are similar in their development, consist-ing of two or more phases. The viraemic phase of TBE has an incubation period of 3-14 days with influenza-like symptoms in the first phase (1-8 days). After a nonfebrile interval of about one week the infection may enter into a second phase, characterised by neurological symptoms of varying intensity. This stage may last for many weeks. At the beginning of the second sickness phase, usually anti-TBE-IgM antibodies are detectable. Antibody levels reach their peak after 2-6 weeks. It can take 10 months for antibodies to fall below the level of detection. Anti-TBE-IgG antibodies are detectable simultaneously or a few days after the appearance of IgM-antibodies. Infection means immunity which mostly lasts a lifetime. Vaccination will also prevent the disease. Regular serological checks establish whether boosters are required. TBE-specific antibodies in Cerebrospinal Fluid (CSF) may be caused by a dysfunction of the hemato-encephalic barrier before or during an immune response to TBE antigens or may be the result of a local immune response. The antibody level fluctuations in the CSF may differ from those prevalent in serum/plasma. With FSME IgM and FSME IG it is possible to differentiate between specific TBE antibodies of the IgG and the IgM classes. Rheumatic factors and specific IgG do not interfere with IgM determination due to the addition of the Rf/IgG-absorber. The combination of both test systems allows the determination of the humoral immune status following TBE-vaccination or inection (IgG), early diagnosis of primary infection with TBE (IgM) and monitoring of changes of antibody levels (IgM/IgG) in human serum, plasma and cerebrospinal fluid.
Species Reactivity: virus
Application: quantitative
Usage: For Lab Research Use Only
Detection Principle: I-ELISA
Storage: Unopened Kit: Store at 2 - 8°C. Do not use past kit expiration date. Opened/Reconstituted Reagents: TMB Solution A; TMB Solution B; TMB Stop Solution; Wash Buffer; HRP-conjugate antibody The above mentioned reagents should be stored for up to 1 month at 2 - 8°C. Microplate Wells: Return unused wells to the foil pouch containing the desiccant pack, reseal along entire edge of zip-seal. May be stored for up to 1 month at 2 - 8°C.

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