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Lactoferrin+Calprotectin Rapid Test Strip Online Inquiry

Cat#:RTS-059
Product Name:Lactoferrin+Calprotectin Rapid Test Strip
Size: 20T
Sample: Stool
Intended use: The Rapid Calprotectin-Lactoferrin test kit is a rapid chromatographic immunoassay (non-invasive assay) for the qualitative detection of calprotectin and lactoferrin in human feces specimens, which might be useful for the diagnosis of inflammatory gastrointestinal disorders.
Gene Introduction: Calprotectin is a calcium-containing protein that makes up 5% of the total protein and 60% of the cytosolic protein of neutrophil. It has bacteriostatic and fungistatic properties and is found in feces at levels six times higher than that in plasma. That fecal biomarker is useful to assess the activity of inflammatory bowel disease (IBD). IBD includes Crohn's Disease (CD) and Ulcerative Colitis (UC) and are associated with elevated neutrophils. This fecal calprotectin assay is useful in differentiating organic (IBD) from functional gastrointestinal disease (IBS: Intestinal Bowel Syndrome). It is a simple, non-invasive biomarker that is especially useful in children, who may require general anesthesia for colonoscopy. And this fecal calprotectin detection can predict relapse. Lactoferrin is a glycoprotein that is produced by neutrophils, mononuclear phagocytes and epithelial cells and is contained in the secretory fluids such as saliva and breast milk. Its function is to block bacterial growth by limiting the availability of iron and this effect is enhanced by the presence of specific secretory IgA antibodies directed against bacteria. Lf also has a bacteriocidal effect by causing direct damage to cell membranes in cooperation with lisozyme. When inflammation develops in the gastrointestinal tract, neutrophils and phagocytic cells migrate to the inflammatory focus and release the granules containing Lf. Lf is stable in faeces and is easily detected for immunochemical methods.
Description: The Rapid Calprotectin-Lactoferrin test kit is a rapid chromatographic immunoassay (non-invasive assay) for the qualitative detection of calprotectin and lactoferrin in human feces specimens, which might be useful for the diagnosis of inflammatory gastrointestinal disorders.
Detection Principle: The Rapid Calprotectin-Lactoferrin test kit is a qualitative lateral flow immunoassay for the detection of human calprotectin and human lactoferrin in human feces samples. The membrane is pre-coated with monoclonal antibodies against human calprotectin and human lactoferrin on the test line regions.
Contents of Kit: 1. Rapid Calprotectin-Lactoferrin Card tests2. Instruction for use3. Specimen collection vials with buffer
Detection Limit: Cut-off value of Calprotectin-Lactoferrin test is 500ng/mL (50μg hCp/g feces) for humancalprotectin and 100ng/mL (10μg hLf/g feces) for human lactoferrin.
Sensitivity: Sensitivity: >94% and specificity 93% compared with Calprest®Eurospital (calprotectin test line).Sensitivity: >99% and specificity >99% compared with IBD EZ VUE® TechLab® (lactoferrin test line).
Storage: Store Rapid Calprotectin-Lactoferrin test strip at 15-25℃, DO NOT FREEZE or use beyond the expiration date. The shelf life of Rapid Calprotectin-Lactoferrin test kit is 12 months.
References: HANAI, H. et al. «“Relationship Between Fecal Calprotectin, Intestinal Inflammation, and Peripheral Blood Neutrophils in Patients with Active Ulcerative Colitis” Digestive Diseases and Sciences, Sept. 2004, Vol 49, No 9, pp 1438-1443.

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