Cat#:PA-895F;Product Name:Sheep Anti-Human Tissue Plasminogen Activator Antibody, biotin-Conjugated;Synonym:PLAT; plasminogen activator, tissue; Tissue Plasminogen Activator; tPA; T-PA; TPA; t-PA; tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); EC 3.4.21.68; DKFZp686I03148; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788;Background:Tissue-type plasminogen activator (tPA) is one of two major physiologic activators of plasminogen in plasma. It is a serine protease of 68 kDa produced primarily in endothelial cells but is also present in monocytes and megakaryocytes. Normal plasma tPA antigen concentrations have been reported from 20ng/ml to 5µg/ml, depending on the assay used, but typically most of the tPA (> 90%) is in complex with its primary inhibitor, plasminogen activator inhibitor-1 (PAI-1). Structurally, tPA is a single-chain enzyme that consists of a catalytic domain followed by two kringle structures, an EGF domain and a finger domain. The activation of plasminogen by tPA is dependent on the presence of a fibrin cofactor. The binding of both tPA and plasminogen to fibrin is mediated in part through lysine binding sites within the kringle structures of both enzyme and substrate, but also through the finger domain of tPA. Activation of plasminogen by tPA occurs by cleavage after residue Arg 560 to produce the two-chain active serine protease plasmin. The activity of tPA is regulated in part by a very short half life in circulation (t½ of ~4 minutes) and by circulating protease inhibitors PAI-1 and to a lesser extent α2 macroglobulin.;Description:Sheep Anti-Human Tissue Plasminogen Activator Polyclonal Antibody, biotin-Conjugated;Host Species:Sheep;Species Reactivity:Human;Isotype:IgG;Application:IEP, ELISA;Storage:Store antibody products at 2-8°C. For long term storage, aliquot and freeze at -20°C. Avoid repeated freeze/thaw cycles;Usage:For Lab Research Use Only;

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Sheep Anti-Human Tissue Plasminogen Activator Antibody, biotin-Conjugated Online Inquiry

Cat#:
PA-895F

Product Name:
Sheep Anti-Human Tissue Plasminogen Activator Antibody, biotin-Conjugated

Synonym:
PLAT; plasminogen activator, tissue; Tissue Plasminogen Activator; tPA; T-PA; TPA; t-PA; tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA); EC 3.4.21.68; DKFZp686I03148; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788

Gene Introduction:
Tissue-type plasminogen activator (tPA) is one of two major physiologic activators of plasminogen in plasma. It is a serine protease of 68 kDa produced primarily in endothelial cells but is also present in monocytes and megakaryocytes. Normal plasma tPA antigen concentrations have been reported from 20ng/ml to 5µg/ml, depending on the assay used, but typically most of the tPA (> 90%) is in complex with its primary inhibitor, plasminogen activator inhibitor-1 (PAI-1). Structurally, tPA is a single-chain enzyme that consists of a catalytic domain followed by two kringle structures, an EGF domain and a finger domain. The activation of plasminogen by tPA is dependent on the presence of a fibrin cofactor. The binding of both tPA and plasminogen to fibrin is mediated in part through lysine binding sites within the kringle structures of both enzyme and substrate, but also through the finger domain of tPA. Activation of plasminogen by tPA occurs by cleavage after residue Arg 560 to produce the two-chain active serine protease plasmin. The activity of tPA is regulated in part by a very short half life in circulation (t½ of ~4 minutes) and by circulating protease inhibitors PAI-1 and to a lesser extent α2 macroglobulin.